Strain evidence
Lacticaseibacillus rhamnosus GG
Probiotic evidence for gut barrier and immune support.
- Form
- Live probiotic culture
- Source
- Healthy human
168
Clinical studies
1,825
Scientific publications
11,457
Clinical participants
Clinically studied benefits
- Digestive health
- Immune health
- Metabolic health
- Oral health
- Pregnancy and infants
- Women's health
- Brain health
Target health outcomes
- Improvement in intestinal permeability (reducing "leaky gut" symptoms).
- Reduction in gastrointestinal sensitivity and support for immune defense.
Recommended population
- Stress-induced digestive sensitivity and postpartum immune support.
- Gut-related skin sensitivity and general inflammatory balance.
Evidence grade
- Human RCTAvailable
- Meta-analysisAvailable
- ObservationalAvailable
- Animal / in vitroAvailable
Mechanism of action
-
Physical attachment
High adhesion to intestinal mucus via pili.
-
Competitive exclusion
Blocks pathogens from colonizing the gut wall.
-
Barrier reinforcement
Stimulates mucin production and tight junction integrity.
-
Result
Enhanced immune resilience and reduced gut inflammation.
Clinical studies
- Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in ChildrenHarvard Medical School
- An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal SymptomsMayo Clinic
- Formula selection for management of children with cow's milk allergy influences the rate of acquisition of tolerance: a prospective multicenter studyJohns Hopkins University
- Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCTUniversity of Oxford
- Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk AllergyUniversity of Naples Federico II
- A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's diseaseMassachusetts General Hospital
- Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GGTufts University
- Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathyWashington University in St. Louis
- Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapyNorth Carolina State University
- Transcriptomic Profile of Whole Blood Cells from Elderly Subjects Fed Probiotic Bacteria Lactobacillus rhamnosus GG ATCC 53103 (LGG) in a Phase I Open Label StudyUniversity of Maryland
Real strains. Real studies.
See the formula that uses this strain, and the evidence behind the rest of our strains.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.